Co-Amoxiclav KAPL Special Precautions

Before initiating the amoxicillin & potassium therapy, a thorough examination of the patient's health record has to be made to ensure that the patient is not allergic to penicillin, cephalosporin or other allergens. In case of the occurrence of allergy with amoxicillin & potassium, the medication should be stopped and the appropriate therapy to be initiated. Pseudomembranous colitis has been reported with antibacterial treatments including amoxicillin & potassium clavulanate. In moderate to severe cases, consideration should be given to management with fluids and electrolytes and treatment with antibacterial drug clinically effective against Clostridium difficile associated colitis. Avoid alcohol (includes wine, beer, and liquid) as alcohol can interfere in the treatment of injection. Diabetic patients should be cautious as glucose urine tests may give false-positive results while using amoxicillin & potassium.
Serious and occasionally fatal hypersensitivity reactions (including anaphylactoid and severe cutaneous adverse reactions) have been reported in patients receiving therapy with beta-lactams. Before initiating therapy with Co-Amoxiclav, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins, carbapenems, or other beta-lactam agents. If an allergic reaction occurs, Co-Amoxiclav must be discontinued immediately and appropriate alternative therapy instituted.
Use in patients with impaired function: Use of amoxicillin & potassium has been associated with cholestatic jaundice and changes in liver function test.
Dose with caution, monitoring the liver function at regular intervals.
Use in the elderly: No dose adjustments are required.